Serotonin Plasma Membrane Transport Proteins

Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SELECTIVE SEROTONIN REUPTAKE INHIBITORS.

Also Known As:

Serotonin Transporter; 5-Hydroxytryptamine Plasma Membrane Transport Protein; 5HT Transporter; Platelet Serotonin Transporter; SERT Proteins; SLC6A4 Protein; Serotonectin; Serotonin Transporter, Platelets; Sodium-Dependent Serotonin Transporter; Solute Carrier Family 6, Member 4 Protein; 5 Hydroxytryptamine Plasma Membrane Transport Protein; Neurotransmitter Transport Proteins, Serotonin Specific; Neurotransmitter Transporters, Serotonin Specific; Platelets Serotonin Transporter; Serotonin Transporter, Platelet; Serotonin Transporter, Sodium-Dependent; Serotonin-Specific Neurotransmitter Transporters; Sodium Dependent Serotonin Transporter; Transporter, Sodium-Dependent Serotonin; Neurotransmitter Transport Proteins, Serotonin-Specific; Neurotransmitter Transporters, Serotonin-Specific; Serotonin Plasma Membrane Transporter Proteins

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Membrane Transport Proteins: 606
      - Ion Pumps: 63
        Symporters: 1513
        Serotonin Plasma Membrane Transport Proteins: 1791
      - Solute Carrier Proteins: 39
        Serotonin Plasma Membrane Transport Proteins: 1791
      - Neurotransmitter Transport Proteins: 24
        Plasma Membrane Neurotransmitter Transport Proteins
        Serotonin Plasma Membrane Transport Proteins: 1791
  - Membrane Proteins: 10262
    - Membrane Transport Proteins: 606
      - Ion Pumps: 63
        Symporters: 1513
        Serotonin Plasma Membrane Transport Proteins: 1791
      - Solute Carrier Proteins: 39
        Serotonin Plasma Membrane Transport Proteins: 1791
      - Neurotransmitter Transport Proteins: 24
        Plasma Membrane Neurotransmitter Transport Proteins
        Serotonin Plasma Membrane Transport Proteins: 1791

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Disease

Drug/Important Bio-Agent (IBA)